Chemical Sampling Information
	Butyl Carbitol
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase ] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: 2-(2-Butoxyethoxy)ethanol; Butoxydiethylene glycol; Butoxydiglycol; Diethylene Glycol Monobutyl Ether; Diethylene Glycol n-Butyl Ether; Dowanol DB OSHA IMIS Code Number: 0471 Chemical Abstracts Service (CAS) Registry Number: 112-34-5 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KJ9100000 Chemical Description and Physical Properties: Colorless liquid molecular formula: C8H18O3 molecular weight: 162.26 boiling point: 230.4°C vapor pressure: 3 Pa @ 20°C flash point: 78°C melting point: -68°C Health Factors Potential symptoms: Eye, skin irritation; high systemic doses in animals caused small decreases in red blood cell count, hemoglobin, hematocrit; enlarged livers and kidney damage Health Effects: Irritation-Eyes---Moderate (HE15) Affected organs: Eyes, skin, liver, kidneys Notes: OSHA does not have a PEL for butyl carbitol, which can form explosive vapor/air mixtures at temperatures above 78°C. Measurement of the metabolite in human urine, 2-(2-butoxyethoxy)acetic acid, has been used for biomonitoring the exposure of floor lacquerers to butyl carbitol. An 8-hr exposure to 0.05 ± 0.03 ppm butyl carbitol resulted in a urinary metabolite concentration of 9.2 ± 7.4 mmol/mol creatinine. A NOAEL of 250 mg/kg/day for butyl carbitol was reported for 13-week oral toxicity studies in rats. Rare cases of allergic contact dermatitis have been reported for individuals exposed to butyl carbinol in printing inks, water-based paints, or disinfectants. Date Last Revised: 09/25/2006 Literature Basis: International Chemical Safety Cards (WHO/IPCS/ILO): Diethylene glycol monobutyl ether. NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: KJ9100000: Ethanol, 2-(2-butoxyethoxy)-. Berlin, K., Johanson, G. and Lindberg, M.: Hypersensitivity to 2-(2-butoxyethoxy)ethanol. Contact Dermatitis 32(1): 54, 1995. Dawson, T.A.J., Black, R.J., Strang, W.C., Millership, J.S. and Davies, I.A.I.: Delayed and immediate hypersensitivity to carbitols. Contact Dermatitis 21(1): 52-53, 1989. Johnson, K.A., Baker, P.C., Kan, H.L., Maurissen, J.P., Spencer, P.J., Marty, M.S.: Diethylene glycol monobutyl ether (DGBE): two- and thirteen-week oral toxicity studies in Fischer 344 rats. Food Chem. Toxicol. 43(3) 467-481, 2005. Laitinen, J. and Pulkkinen, J.: Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids. Toxicol. Lett. 156(1): 117-126, 2005. Schliemann-Willers, S., Bauer, A. and Elsner, P.: Occupational contact dermatitis from diethylene glycol monobutyl ether in a podiatrist. Contact Dermatitis 43(4): 225, 2000. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Charcoal Tubes (100/50 mg sections; 20/40 mesh) analytical solvent: (95:5) Methylene Chloride:Methanol maximum volume: 10 Liters   maximum flow rate: 0.2 L/min current analytical method: Gas Chromatography; GC/FID method reference: OSHA Analytical Method (OSHA PV2095) method classification: Partially Validated All Trademarks are the property of their respective owners.