 |
Chemical Sampling Information |
|
| Diethylene Glycol Monoethyl Ether |
|
General Description
Synonyms: Carbitol; Carbitol Cellosolve; DEGEE; Poly-Solv; Solvosol; 2-(2-Ethoxyethoxy)-Ethanol
OSHA IMIS Code Number: D615
Chemical Abstracts Service (CAS) Registry Number: 111-90-0
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KK8750000
Chemical Description and Physical Properties: Clear liquid with a mildly sweet odor
molecular formula: C6H14O3
molecular weight: 134.17
boiling point: 197°C
vapor pressure: 19 Pa @ 25°C
melting point: -76°C
Health Factors
Potential symptoms: Eye, skin irritation; high systemic doses in animals caused CNS depression (ataxia, lethargy, coma), pulmonary edema, anemia, enlarged livers and kidney damage.
Health Effects: Irritation-Eye, Skin---Mild (HE16); Kidney damage (HE3); Nervous system disturbances---Narcosis (HE8); Lung edema (HE11).
Affected organs: Kidneys, respiratory system, eyes, skin, CNS
Notes: 1) OSHA does not have a PEL for diethylene glycol monoethyl ether (DEGEE). 2) The major urinary metabolite of DEGEE in humans is 2-(2-ethoxyethoxy) acetic acid. 3) Repeated-dose inhalational studies of DEGEE in rats indicated a NOAEL of 0.09 mg/liter for irritation of the upper respiratory tract and 1.1 mg/liter for systemic effects. 4) Three cases of severe kidney damage and coma led the French Health Products Sanitary Safety Agency to withdraw an OTC diuretic drug (Pilosuryl) from the market in June 2003, having attributed the toxicity to the excipient, DEGEE.
Date Last Revised: 03/29/2005
Literature Basis:
- International Chemical Safety Cards (WHO/IPCS/ILO): Diethylene glycol monoethyl ether.
- NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: KK8750000: Ethanol, 2-(2-ethoxyethoxy)-.
- Gaunt, I.F., Colley, J., Grasso, P., Lansdown, A.B.G. and Gangolli, S.D.: Short-term toxicity of diethylene glycol monoethyl ether in the rat, mouse and pig. Food Cosmet. Toxicol. 6(6): 689-705, 1968.
- Hardy, C.J., Coombs, D.W., Lewis, D.J. and Klimisch, H.J.: Twenty-eight-day repeated-dose inhalation exposure of rats to diethylene glycol monoethyl ether. Fundam. Appl. Toxicol. 38(2): 143-147, 1997.
- Miller, R.R.: Metabolism and disposition of glycol ethers. Drug. Metab. Rev. 18(1): 1-22, 1987.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
-
sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: (95:5) Methylene Chloride:Methanol (v/v)
maximum volume: 10 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA PV2013)
method classification: Partially Validated
* All Trademarks are the property of their respective owners.
|
|
|
|
 |
|
Back to Top
www.osha.gov
