Chemical Sampling Information
	Dimethyl sulfide
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: Methyl Sulfide; Dimethyl Sulphide; Thiobismethane; DMS; Methylthiomethane; 2-Thiapropane; 2-Thiopropane OSHA IMIS Code Number: D650 Chemical Abstracts Service (CAS) Registry Number: 75-18-3 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: PV5075000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1164 130 [27 KB, PDF] Chemical Description and Physical Properties: flammable, colorless liquid with characteristic odor molecular formula: C2H6S molecular weight: 62.14 boiling point: 37.3°C flash point: -49°C melting point: -98°C vapor pressure: 53.2 kPa @ 20°C Potentially hazardous incompatibilities: reacts violently with oxidants causing fire and explosion hazard Exposure Limits American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 ppm, 25 mg/m3 TWA Health Factors Potential symptoms: Irritation of eyes and skin; cough, sore throat; nausea; weakness. Health Effects: : Irritation-Eyes---Marked (HE14); Irritation-Skin---Mild (HE16). Affected organs: Eyes, skin, respiratory system Notes: OSHA does not have a PEL for dimethyl sulfide. Vapor/air mixtures of dimethyl sulfide may be explosive. Dimethyl sulfide is listed by the FDA as a synthetic flavoring substance that is permitted for direct addition to food for human consumption (21 CFR 172.515). Dimethyl sulfide is a minor metabolite of the amino acid methionine, the drug cysteamine, and dimethylsulfoxide, and it can be measured in breath, blood and urine. Hematological health effects of organic sulfide exposure on employees at a pulp and paper plant have been studied, but the role of dimethyl sulfide in these effects is unknown. Date Last Revised: 02/06/2007 Literature Basis: International Chemical Safety Cards (WHO/IPCS/ILO): Dimethylsulphide. Blom, H.J., Boers, G.H., van den Elzen, J.P., Gahl, W.A. and Tangerman, A.: Transamination of methionine in humans. Clin. Sci. (Lond.) 76(1): 43-49, 1989. Egorin, M.J., Rosen, D.M., Sridhara, R., Sensenbrenner, L. and Cottier-Fox, M.: Plasma concentrations and pharmacokinetics of dimethylsulfoxide and its metabolites in patients undergoing peripheral-blood stem-cell transplants. J. Clin. Oncol. 16(2): 610-615, 1998. Gahl, W.A., Ingelfinger, J., Mohan, P., Bernardini, I., Hyman, P.E. and Tangerman, A.: Intravenous cysteamine therapy for nephropathic cystinosis. Pediatr. Res. 38(4): 579-584, 1995. Klingberg, J., Beviz, A., Ohlson, C.G. and Tenhunen, R.: Disturbed iron metabolism among workers exposed to organic sulfides in a pulp plant. Scand. J. Work Environ. Health 14(1): 17-20, 1988. Pohanish, R.P. (editor): Dimethyl Sulfide. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 941-942. Suarez, F.L., Furne, J.K., Springfield, J. and Levitt, M.D.: Morning breath odor: influence of treatments on sulfur gases. J. Dent. Res. 79(10): 1773-1777, 2000. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) analytical solvent: Methylene Chloride maximum volume: 5 Liters   maximum flow rate: 0.1 L/min current analytical method: Gas Chromatography; GC/FPD method reference: OSHA SLTC In-House Files method classification: Partially Validated All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.