Chemical Sampling Information
	Isophorone
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: Isoacetophorone; 3,5,5-Trimethyl-2-cyclohexene-1-one; 3,5,5-Trimethyl-2-cyclohexenone; 3,5,5-Trimethyl-2-cyclo-hexen-1-one OSHA IMIS Code Number: 1538 Chemical Abstracts Service (CAS) Registry Number: 78-59-1 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: GW7700000 Department of Transportation Regulation Number (49 CFR 172.101) and guide [2008 Emergency Response Guidebook, 2.5 MB PDF]: 1993 128 (combustible liquid, n.o.s.) NIOSH Pocket Guide to Chemical Hazards, Isophorone: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 25 ppm, 140 mg/m3 TWA OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 25 ppm, 140 mg/m3 TWA OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 25 ppm, 140 mg/m3 TWA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 28 mg/m3 Ceiling; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 4 ppm, 23 mg/m3 TWA Health Factors Environmental Protection Agency (EPA) carcinogenic classification: Group C, possible human carcinogen NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 200 ppm Potential symptoms: Irritation of eyes, nose, throat; cough, sore throat; shortness of breath; headache, nausea, dizziness, lassitude (weakness, exhaustion); malaise (vague feeling of discomfort), narcosis; blurred vision; dry, cracking skin, dermatitis; in animals: kidney, liver damage. Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Acute CNS effects (HE4). Affected organs: Eyes, skin, respiratory system, CNS, liver, kidneys Notes: Above 84ºC, explosive vapor/air mixtures may be formed. EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for isophorone is 0.2 mg/kg/day, and EPA’s provisional reference concentration is 12 µg/m3. The concentration of isophorone causing a 50% decrease in the respiratory rate of mice (a measure of sensory irritation) was reported to be 27.8 ppm. Date Last Revised: 06/29/2006 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: Isophorone. International Chemical Safety Cards (WHO/IPCS/ILO): Isophorone. EPA Air Toxics Website: Isophorone. U.S. Environmental Protection Agency Technology Transfer Network. De Ceaurriz, J., Micillino, J.C., Bonnet, P. and Guenier, J.P.: Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett. 9(2): 137-143, 1981. Pohanish, R.P. (editor): Isophorone. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1342-1344. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Petroleum Base Charcoal Tube (100/50 mg sections, 20/40 mesh) analytical solvent: Carbon Disulfide alternate analytical solvent: (99:1) Carbon Disulfide:Dimethylformamide maximum volume: 12 Liters   maximum flow rate: 0.2 L/min current analytical method: Gas Chromatography; GC/FID method reference: NIOSH Analytical Method (NIOSH 2508) [20 KB, PDF] method classification: Fully Validated note: The flowrate was dropped to 0.2 L/min on May 11, 1995 since in the 4th edition of NIOSH methods it states that the breakthrough was performed at 0.19 L/min but no data is given for 1 L/min. sampling media: XAD-4 (80/40 mg sections, 20/40 mesh) analytical solvent: diethyl ether maximum volume: 25 Liters   maximum flow rate: 0.2 L/min current analytical method: Gas Chromatography; GC/FID method reference: NIOSH Analytical Method (NIOSH 2556) [80 KB, PDF] method classification: Partially Validated note: Samples should be refrigerated as soon as possible after sampling and sent cold to the laboratory. All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Technical Support and Emergency Management at 202-693-2300 for assistance accessing PDF materials.