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Chemical Sampling Information |
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| N-Nitrosodipropylamine |
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General Description
Synonyms: NDPA; Di-n-propylnitrosamine; N-Nitrosodi-n-propylamine; DPNA; DPN; N-Nitroso-N-propyl-1-propanamine; propylamine, N-Nitroso-N-di; Dipropylnitrosamine; N-Propyl-N-nitrosopropylamine
OSHA IMIS Code Number: 1948
Chemical Abstracts Service (CAS) Registry Number: 621-64-7
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: JL9700000
Chemical Description and Physical Properties: Liquid
molecular formula: C6H14N20
molecular weight: 130.2
boiling point: 194.5°C
vapor pressure: 997.582 mmHg @ 31.1111°C
flash point: 98.89°C
Health Factors
National Toxicology Program (NTP) carcinogenic classification: Reasonably Anticipated to be a Human Carcinogen
International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans (N-Nitrosodi-n-propylamine)
Environmental Protection Agency (EPA) carcinogenic classification: Group B2, Probable human carcinogen.
Potential symptoms: Irritation of eyes, skin; in animals: liver damage; [potential occupational carcinogen]
Health Effects: Animal carcinogen (liver, lung, esophagus, nasal/paranasal) (HE2).
Affected organ: Liver
Notes:
- N-Nitrosodipropylamine is an OSHA Select Carcinogen. OSHA does not have a PEL for this chemical.
- Absorption of N-nitrosodipropylamine through human skin has been demonstrated.
- N-Nitrosodipropylamine undergoes activation by cytochrome P450 2E1 to metabolites that result in the chemical modification of DNA (N7 alkylation of guanine nucleotides). Other potential metabolites include propionaldehyde, propylamine, nitric oxide and nitrite.
- The co-administration of ethanol, a known inducer of hepatic CYP2E1, was reported to enhance the carcinogenicity of chronic oral N-nitrosodipropylamine in mice.
- In 2005, the California Department of Health Services established a notification level for N-nitrosodipropylamine of 10 nanograms per liter of drinking water after finding it (and N-nitrosodimethylamine) in some resins being evaluated for drinking water treatment.
Date Last Revised: 11/14/2005
Literature Basis:
- U.S. EPA Integrated Risk Information System: N-Nitrosodi-N-propylamine (CASRN 621-64-7).
- Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profile for N-nitrosodi-n-propylamine. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, 1989.
- California Department of Health Services: California drinking water; activities related to NDMA and other nitrosamines, 2005.
- No Author: N-Nitrosodi-n-Propylamine, CAS No. 621-64-7. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2005.
- Pohanish, R.P. (editor): N-Nitrosodipropylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1736-1738.
- Teiber, J.F. and Hollenberg, P.F.: Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine. Carcinogenesis 21(8): 1559-1566, 2000.
- Teiber, J.F., Macé, K. and Hollenberg, P.F.: Metabolism of the β-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-β-hydroxypropylpropylamine and N-nitroso-β-oxypropylpropylamine. Carcinogenesis 22(3): 499-506, 2001.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: ThermoSorb/N Tube
analytical solvent: 75/25 (v/v) Dichloromethane/Methanol
maximum volume: 75 Liters maximum flow rate: 1.0 L/min
current analytical method: Gas Chromatography; GC/TEA
method reference: OSHA Analytical Method (OSHA 27)
method classification: Fully Validated
note: OSHA personnel may obtain ThermoSorb/N Tube from SLTC. Store samples in freezer.
Bulk method: Limit the amount of bulk submitted to one gram or one mL.
* All Trademarks are the property of their respective owners.
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