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Chemical Sampling Information |
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| 2-Pentanone |
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General Description
Synonyms: Methyl propyl ketone; Ethyl acetone; MPK
OSHA IMIS Code Number: 2010
Chemical Abstracts Service (CAS) Registry Number: 107-87-9
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: SA7875000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1249 127
NIOSH Pocket Guide to Chemical Hazards, 2-Pentanone: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 200 ppm, 700 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 200 ppm, 700 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 200 ppm, 700 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 200 ppm, 705 mg/m3 TWA; 250 ppm, 881 mg/m3 STEL (TLV listed under Methyl propyl ketone)
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 150 ppm, 530 mg/m3 TWA
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,500 ppm
Potential symptoms: Irritation of eyes, skin, mucous membrane; cough, sore throat; headache; dry, cracked skin, dermatitis; dizziness, drowsiness, narcosis, coma; INGES. ACUTE: Abdominal pain, nausea.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Narcosis (HE8)
Affected organs: Eyes, skin, respiratory system, CNS
Notes:
- Vapor/air mixtures may be explosive.
- Listed among FDA’s “food additives permitted for direct addition to food for human consumption” (21 CFR 172.515).
- 2-Pentanone was identified among the VOCs found in the breath of rats, and its concentration was increased by an inhibitor of cytochrome P450 2E1.
Date Last Revised: 05/22/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: 2-Pentanone.
- International Chemical Safety Cards (WHO/IPCS/ILO): Methyl propyl ketone.
- Mathews, J.M., Raymer, J.H., Etheridge, A.S., Velez, G.R. and Bucher, J.R.: Do endogenous volatile organic chemicals measured in breath reflect and maintain CYP2E1 levels in vivo? Toxicol. Appl. Pharmacol. 146(2): 255-260, 1997.
- Pohanish, R.P. (editor): 2-Pentanone. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1808-1810.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Carbon Disulfide
maximum volume: 10 Liters maximum flow rate: 0.2 L/min (TWA)
maximum volume: 3 Liters maximum flow rate: 0.2 L/min (STEL)
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 1300)
method classification: Fully Validated
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