2-ETHOXYETHANOL (CELLOSOLVE; GLYCOL MONOETHYL ETHER) | Occupational Safety and Health Administration

2-ETHOXYETHANOL (CELLOSOLVE; GLYCOL MONOETHYL ETHER)†

Chemical Identification
CAS #	110-80-5
Formula	C₄H₁₀O₂
Synonyms	Cellosolve; EGEE; ethylene glycol monoethyl ether

Physical Properties
Physical description	Colorless liquid with a sweet, pleasant, ether-like odor.
Boiling point	275°F	Molecular weight	90.14.
Freezing point/melting point	-94°F	Vapor pressure	4 mmHg
Flash point	105°F	Vapor density	3.1
Specific gravity	0.93	Ionization potential
Lower explosive limit (LEL)	1.8%	Upper explosive limit (UEL)	14%
NFPA health rating	1	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1033
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA 53 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	200 ppm (740 mg/m³)	REL-TWA	0.5 ppm (18 mg/m³)	TLV-TWA	5 ppm [1981]	PEL-TWA	5 ppm (18 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	Y	Skin notation	Y	Skin notation	Y	Skin notation	Y
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes: BEI®		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	500 ppm
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Ethylene glycol monoethyl ether

NIOSH: Pocket Guide to Chemical Hazards - 2-Ethoxyethanol

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 2-Ethoxyethanol. See annual publication for most recent information.
U.S. EPA Integrated Risk Information System: 2-Ethoxyethanol (CASRN 110-80-5).
MMWR: Criteria for a recommended standard: occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates. Morbidity and mortality weekly report 41(21): 386, 1992.
Groeseneken, D., Veulemans, H. and Masschelein, R: Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycol monoethyl ether. Br. J. Ind. Med. 43(9): 615-619, 1986.
Johnson, W., Jr., Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Int. J. Toxicol. 21(Suppl. 1): 9-62, 2002.
Kežić, S., Mahieu, K., Monster, A.C. and de Wolff, F.A.: Dermal absorption of vaporous and liquid 2-methoxyethanol and 2-ethoxyethanol in volunteers. Occup. Environ. Med. 54(1): 38-43, 1997.
Pohanish, R.P. (editor): 2-Ethoxyethanol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1035-1037.
Zissu, D.: Experimental study of cutaneous tolerance to glycol ethers. Contact Dermatitis 32(2): 74-77, 1995.

Last Updated Date : 09/21/2022

2-ETHOXYETHANOL (CELLOSOLVE; GLYCOL MONOETHYL ETHER)†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References