2-ETHOXYETHYL ACETATE (CELLOSOLVE ACETATE) | Occupational Safety and Health Administration

2-ETHOXYETHYL ACETATE (CELLOSOLVE ACETATE)†

Chemical Identification
CAS #	111-15-9
Formula	C₆H₁₂O₃
Synonyms	2-ethoxyethyl acetate; cellosolve acetate; EGEEA; ethylene glycol monoethyl ether acetate; glycol monoethyl ether acetate

Physical Properties
Physical description	Colorless liquid with a mild odor.
Boiling point	313°F	Molecular weight	132.2
Freezing point/melting point	-79°F	Vapor pressure	2 mmHg
Flash point	135°F	Vapor density	4.72
Specific gravity	0.98	Ionization potential
Lower explosive limit (LEL)	1.7%	Upper explosive limit (UEL)	6.7%
NFPA health rating	2	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1037
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA 53 (fully validated)
Notes	Keep samples refrigerated when not in transit. Ship samples overnight with cold-packs as soon as possible.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media	Wipe with charcoal pad, seal in glass vial for shipment. [3M 3500]
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	100 ppm (540 mg/m³)	REL-TWA	0.5 ppm (2.7 mg/m³)	TLV-TWA	5 ppm [1981]	PEL-TWA	5 ppm (27 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	Y	Skin notation	Y	Skin notation	Y	Skin notation	Y
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes: BEI®		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	500 ppm
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Ethylene glycol monoethyl ether acetate

NIOSH: Pocket Guide to Chemical Hazards - 2-Ethoxyethyl acetate

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 2-Ethoxyethyl acetate. See annual publication for most recent information.
MMWR: Criteria for a recommended standard: occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates. Morbidity and mortality weekly report 41(21): 386, 1992.
Dugard, P.H., Walker, M., Mawdsley, S.J. and Scott, R.C.: Absorption of some glycol ethers through human skin in vitro. Environ. Health Perspect. 57: 193-197, 1984.
Johnson, W., Jr., Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Int. J. Toxicol. 21(Suppl. 1): 9-62, 2002.
Nelson, B.K., et al.: Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats. Environ. Health Perspect. 57: 261-271, 1984.
Pohanish, R.P. (editor): 2-Ethoxyethyl Acetate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1037-1039.
Söhnlein, B., Letzel, S., Weltle, D., Rüdiger, H.W. and Angerer, J.: Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers. Int. Arch. Occup. Environ. Health 64(7): 479-484, 1993.
Stott, W.T. and McKenna, M.J.: Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro. Fundam. Appl. Toxicol. 5(2): 399-404, 1985.
Zissu, D.: Experimental study of cutaneous tolerance to glycol ethers. Contact Dermatitis 32(2): 74-77, 1995.

Last Updated Date : 09/21/2022

2-ETHOXYETHYL ACETATE (CELLOSOLVE ACETATE)†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References