DIETHANOLAMINE

Chemical Identification
CAS #	111-42-2
Formula	C₄H₁₁NO₂
Synonyms	DEA; di(2-hydroxyethyl)amine; 2,2'-dihydroxydiethyamine; diolamine; bis(2-hydroxyethyl)amine; 2,2'-iminodiethanol

Physical Properties
Physical description	Colorless crystals or a syrupy, white liquid (above 82°F) with a mild, ammonia-like odor.
Boiling point	516°F (decomposes)	Molecular weight	105.2
Freezing point/melting point	82°F	Vapor pressure	<0.01 mmHg
Flash point	279°F	Vapor density	3.65
Specific gravity	1.1	Ionization potential
Lower explosive limit (LEL)	1.6%	Upper explosive limit (UEL)	9.8%
NFPA health rating	3	NFPA fire rating	1
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	D129
Sampling group
Sampler/Sampling media	XAD-2 tube (80/40) coated with 10% 1-naphthylisothiocyanate (NITC) [SKC 226-30-18]
Sampling time^*	100 min
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC-UV
Method reference	OSHA PV2018 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA	3 ppm (15 mg/m³)	TLV-TWA	1 mg/m³ (inhalable fraction and vapor) [2008]	PEL-TWA	0.46 ppm (2 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	N	Skin notation	Y	Skin notation	Y
Notes: Not established		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-3, TLV-A3		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Diethanolamine

NIOSH: Pocket Guide to Chemical Hazards - Diethanolamine

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Diethanolamine. See annual publication for most recent information.
EPA Air Toxics Website: Diethanolamine. U.S. Environmental Protection Agency Technology Transfer Network.
International Chemical Safety Cards (WHO/IPCS/ILO): Diethanolamine.
Mathews, J.M., Garner, C.E. and Matthews, H.B.: Metabolism, bioaccumulation, and incorporation of diethanolamine into phospholipids. Chem. Res. Toxicol. 8(5): 625-633, 1995.
Mirer, F.: Updated epidemiology of workers exposed to metalworking fluids provides sufficient evidence for carcinogenicity. Appl. Occup. Environ. Hyg. 18(11):902-912, 2003.
National Toxicology Program: NTP Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies). Natl. Toxicol. Program Tech. Rep. Ser. 478: 1-212, 1999.
Piipari, R., et al.: Diethanolamine-induced occupational asthma, a case report. Clin. Exp. Allergy 28(3): 358-362, 1998.
Pohanish, R.P. (editor): Diethanolamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 860-862.

Last Updated Date : 12/28/2020

DIETHANOLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References