DIMETHYLACETAMIDE | Occupational Safety and Health Administration

DIMETHYLACETAMIDE†

Chemical Identification
CAS #	127-19-5
Formula	C₄H₉NO
Synonyms	N,N-dimethyl acetamide; DMAC; acetic acid dimethylamide

Physical Properties
Physical description	Colorless liquid with a weak, ammonia- or fish-like odor.
Boiling point	329°F	Molecular weight	87.1
Freezing point/melting point	-4°F	Vapor pressure	2 mmHg
Flash point	158°F (open cup)	Vapor density
Specific gravity	0.94	Ionization potential	8.81 eV
Lower explosive limit (LEL)	1.8% at 212°F	Upper explosive limit (UEL)	11.5% at 320°F
NFPA health rating	2	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0927
Sampling group
Sampler/Sampling media	Silica gel tube (150/75 mg) [SKC 226-10]
Sampling time^*
Sampling volume (TWA)^*	80 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	NIOSH 2004 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	10 ppm (35 mg/m³)	REL-TWA	10 ppm (35 mg/m³)	TLV-TWA	10 ppm [2017]	PEL-TWA	10 ppm (35 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	Y	Skin notation	Y	Skin notation	Y	Skin notation	Y
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes: BEI®		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	300 ppm
Carcinogenic classifications: TLV-A3		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Dimethylacetamide

NIOSH: Pocket Guide to Chemical Hazards - Dimethyl acetamide

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Dimethylacetamide. See annual publication for most recent information.
Lee, C.-Y., Jung, S.-J., Kim, S.-A., Park, K.-S. and Ha, B.-G. Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers. Occup. Environ. Med. 63(10): 688-693, 2006.
Nimiyama, T., et al. Dermal absorption of N,N-dimethylacetamide in human volunteers. Int. Arch. Occup. Environ. Health 73(2): 121-126, 2000.
Okuda, H., et al. Developmental toxicity induced by inhalation exposure of pregnant rats to N,N-dimethylacetamide. J. Occup. Health 48(3): 154-160, 2006.
Perbellini, L., Princivalle, A., Caivano, M. and Montagnani, R. Biological monitoring of occupational exposure to N,N-dimethylacetamide with identification of a new metabolite. Occup. Environ. Med. 60(1): 746-751.
Pohanish, R.P. (editor) N,N-Dimethylacetamide. In Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 905-907.

Last Updated Date : 12/28/2020

DIMETHYLACETAMIDE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References