4,4'-METHYLENE BIS(2-CHLOROANILINE)

Chemical Identification
CAS #	101-14-4
Formula	C₁₃H₁₂Cl₂N₂
Synonyms	DACPM; 3,3'-dichloro-4,4'-diaminodiphenylmethane; MBOCA; 4,4'-methylenebis(o-chloro aniline); 4,4'-methylenebis(2-chlorobenzenamine); MOCA

Physical Properties
Physical description	Tan-colored pellets or flakes with a faint, amine-like odor.
Boiling point		Molecular weight	267.2
Freezing point/melting point	210-225°F	Vapor pressure	0.00001 mmHg at 77°F
Flash point		Vapor density	`
Specific gravity	1.44	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	2650
Sampling group
Sampler/Sampling media	2 GFFs (37 mm) coated with sulfuric acid, in 3-piece cassette, separated by the ring section [SKC 225-9004]
Sampling time^*
Sampling volume (TWA)^*	100 L
Sampling flow rate (TWA)^*	1.0 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-ECD
Method reference	OSHA 71 (fully validated)
Notes	Within 10 hours after sampling, transfer filter to glass vial containing 2 mL deionized water.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media	Wipe with GFF (37 mm), Type A/E [AP4003705]. Place wipe sample into a glass vial containing 2 mL of 0.01 N sulfuric acid.
Bulk Method	Limit the amount of bulk submitted to 1 g or 1 mL.

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA	0.003 mg/m³	TLV-TWA	0.01 ppm (inhalable fraction and vapor) [1991]	PEL-TWA	0.01 mg/m³
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	Y	Skin notation	Y	Skin notation	Y
Notes: Not established		Notes: CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION. See Appendix A, NIOSH Potential Occupational Carcinogens.		Notes: BEI®		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-1, NIOSH-Ca, NTP-R, TLV-A2		Notes: Ca
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - 4,4'-Methylenebis(2-chloroaniline)

NIOSH: Pocket Guide to Chemical Hazards - 4,4'-Methylenebis(2-chloroaniline)

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 4,4'-Methylene bis(2-chloroaniline). See annual publication for most recent information.
Chen, T.H., Kuslikis, B.I. and Braselton, W.E., Jr.: Unlabeled hemoglobin adducts of 4,4';-methylenebis(2-chloroaniline) in rats and guinea pigs. Arch. Toxicol. 65(3): 177-185, 1991.
Cocker, J., Boobie, A.R., Wilson, H.K. and Gompertz, D.: Evidence that a beta-N-glucuronide of 4,4'-methylenebis(2-chloroaniline) (MbOCA) is a major urinary metabolite in man: implications for biological monitoring. Br. J. Ind. Med. 47(3): 154-161, 1990.
Ichikawa, Y., Yoshida, M., Okayama, A., Hara, I. and Morimoto, K.: Biological monitoring for workers exposed to 4,4'-methylenebis(2-chloroaniline). Am. Ind. Hyg. Assoc. J. 51(1): 5-7, 1990.
Liu, C.-S., et al.: Occupational bladder cancer in a 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed worker. Environ. Health Perspec. 113(6): 771-774, 2005.
No Author: 4,4'-Methylenebis(2-Chloroaniline) (CAS No. 101-14-4). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2011.
Pohanish, R.P. (editor): 4,4'-Methylenebis(2-Chloroaniline). In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1553-1556.

Last Updated Date : 12/15/2020

4,4'-METHYLENE BIS(2-CHLOROANILINE)

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References