1,3,5-TRIGLYCIDYL-S-TRIAZINETRIONE

Chemical Identification
CAS #	2451-62-9
Formula	C₁₂H₁₅N₃O₆
Synonyms	TGIC, triglycidyl isocyanurate, 1,3,5-triglycidyl isocyanurate, TGT, glycidyl isocyanurate, tris(epoxypropyl)isocyanurate, s-triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2,3-epoxypropyl)-s-triazine-2,4,6(1H,3H,5H)-trione. [1,3,5-triglycidyl isocyanurate (TGIC) has two stereoisomers, α and β]

Physical Properties
Physical description	White crystalline solid.
Boiling point		Molecular weight	297.27
Freezing point/melting point	203-208°F	Vapor pressure
Flash point		Vapor density
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	T405
Sampling group
Sampler/Sampling media	GFF (37 mm), Type A/E [AP4003705]
Sampling time^*	180 min
Sampling volume (TWA)^*	180 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA 1024 (fully validated)
Notes	Samples must be shipped cold overnight and stored in a freezer until analysis.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA	0.05 mg/m³ [1994]	PEL-TWA	0.005 mg/m³
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	N	Skin notation	N
Notes: Not established		Notes: Not established		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Tris(2, 3-Epoxypropyl)isocyanurate

NIOSH: Pocket Guide to Chemical Hazards - Tris(2, 3-Epoxypropyl)isocyanurate

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 1,3,5-Triglycidyl-s-triazinetrione. 2017.
Allmaras, S.: Worker exposure to 1,3,5-tryglycidyl isocyanurate (TGIC) in powder paint coating operations. Appl. Occup. Environ. Hyg. 18(3): 151-153, 2003.
Anees W, Moore VC, Croft JS, Robertson AS, Burge PS: Occupational asthma caused by heated triglycidyl isocyanurate. Occup Med (Lond) 61(1):65-7, Jan 2011.
Lindell, B. and Montelius, J: Triglycidyl isocyanurate [114 KB PDF, 36 pages]. Arbete och Hälsa 18: 1-30, 2001.
Meuleman L, Goossens A, Linders C, Rochette F, Nemery B: Sensitization to triglycidylisocyanurate (TGIC) with cutaneous and respiratory manifestations. Allergy 54(7):752-6, July 1999.
Piirilä P, Estlander T, Keskinen H, Jolanki R, Laakkonen A, Pfäffli P, Tupasela O, Tuppurainen M, Nordman H.Occupational asthma caused by triglycidyl isocyanurate (TGIC). Clin Exp Allergy 27(5):510-4, May 1997.
Sastre J, Carnes J, García del Potro M, Manso L, Aguado E, Fernández-Nieto M: Occupational asthma caused by triglycidyl isocyanurate. Int Arch Occup Environ Health. 84(5):547-9, Jun 2011.
World Health Organization (WHO): Triglycidyl Isocyanurate. 1998.

Last Updated Date : 12/14/2020

1,3,5-TRIGLYCIDYL-S-TRIAZINETRIONE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References