BROMOFORM | Occupational Safety and Health Administration

BROMOFORM†

Chemical Identification
CAS #	75-25-2
Formula	CHBr₃
Synonyms	methyl tribromide; tribromomethane

Physical Properties
Physical description	Colorless to yellow liquid with a chloroform-like odor.
Boiling point	301°F	Molecular weight	252.8
Freezing point/melting point	47°F	Vapor pressure	5 mmHg
Flash point		Vapor density	8.7
Specific gravity	2.89	Ionization potential	10.48 eV
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0400
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	NIOSH 1003 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media	Wipe with charcoal pad, seal in glass vial for shipment. [3M 3500]
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	0.5 ppm (5 mg/m³)	REL-TWA	0.5 ppm (5.2 mg/m³)	TLV-TWA		PEL-TWA	0.5 ppm (5 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	Y	Skin notation	Y	Skin notation	N	Skin notation	Y
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes: Visit the ACGIH TLV site for specific data		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	850 ppm
Carcinogenic classifications: EPA-B2, IARC-3, TLV-A3		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Bromoform

NIOSH: Pocket Guide to Chemical Hazards - Bromoform

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Bromoform. See annual publication for most recent information.
EPA Air Toxics Website: Bromoform. U.S. Environmental Protection Agency Technology Transfer Network.
Fantuzzi, G., Righi, E., Predieri, G., Ceppelli, G., Gobba, F. and Aggassotti, G.: Occupational exposure to trihalomethanes in indoor swimming pools. Sci. Total Environ. 264(3): 257-265, 2001.
Kash, T.L., Jenkins, A. and Harrison, N.L.: Molecular volume determines the activity of the halogenated alkane bromoform at wild-type and mutant GABA(A) receptors. Brain Res. 960(1-2): 36-41, 2003.
Pohanish, R.P. (editor): Bromoform. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 377-379.
Anders, M.W., Stevens, J.L., Sprague, R.W., Shaath, Z. and Ahmed, A.E.: Metabolism of haloforms to carbon monoxide. II. In vivo studies. Drug Metab. Dispos. 6(5): 556-560, 1978.
Xu, X., Mariano, T.M., Laskin, J.D. and Weisel, C.P.: Percutaneous absorption of trihalomethanes, haloacetic acids, and haloketones. Toxicol. Appl. Pharmacol. 184(1): 19-26, 2002.

Last Updated Date : 04/03/2024

BROMOFORM†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References