CHLORODIFLUOROMETHANE

Chemical Identification
CAS #	75-45-6
Formula	CHClF₂
Synonyms	difluorochloromethane; Fluorocarbon-22, Freon22; Genetron22; monochlorodifluoromethane; Refrigerant 22

Physical Properties
Physical description	Colorless gas with a faint, sweet odor.
Boiling point	-41°F	Molecular weight	86.5
Freezing point/melting point	"-231°F"	Vapor pressure	9.4 atm
Flash point		Vapor density	3.11
Specific gravity	1.41 at -40°F	Ionization potential	12.45 eV
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)
Sampling group
Sampler/Sampling media
Sampling time^*
Sampling volume (TWA)^*
Sampling flow rate (TWA)^*
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments
Method reference
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA	1000 ppm (3500 mg/m³)	TLV-TWA	1000 ppm [1990]	PEL-TWA	1000 ppm (3500 mg/m³)
PEL-STEL		REL-STEL	1250 ppm (4375 mg/m³)	TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	N	Skin notation	N	Skin notation	N
Notes: Not established		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-3, TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Chlorodifluoromethane

NIOSH: Pocket Guide to Chemical Hazards - Chlorodifluoromethane

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Chlorodifluoromethane. See annual publication for most recent information.
U.S. EPA Integrated Risk Information System: Chlorodifluoromethane (CASRN 75-45-6).
Kintz, P., Baccino, E., Tracqui, A. and Mangin, P.: Headspace GC/MS testing for chlorodifluoromethane in two fatal cases. Forensic Sci. Int. 82(2): 171-175, 1996.
Kubota, T. and Miyata, A.: Acute inhalational exposure to chlorodifluoromethane (Freon-22): a report of 43 cases. Clin. Toxicol. (Phila.) 43(4): 305-308, 2005.
Nieuwenhuizen, M.S. and Groeneveld, F.R.: Formation of phosgene during welding activities in an atmosphere containing chlorinated hydrocarbons. AIHAJ 61(4): 539-543, 2000.
Pohanish, R.P. (editor): Chlorodifluoromethane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 565-567.
Woollen, B. H., et al.: Human inhalation pharmacokinetics of chlorodifluoromethane (HCFC22). Int. Arch. Occup. Environ. Health 64(5): 383-387, 1992.

Last Updated Date : 01/31/2018

CHLORODIFLUOROMETHANE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References