AZINPHOS-METHYL (GUTHION) | Occupational Safety and Health Administration

AZINPHOS-METHYL (GUTHION)†

Chemical Identification
CAS #	86-50-0
Formula	C₁₀H₁₂N₃O₃PS₂
Synonyms	guthion; O,o-dimethyl S-4-oxo-1,2,3-benzotriazin-3(4H)-ylmethyl phosphorodithioate; phosphorodithioic acid, O,o-dimethyl ester, S-ester with 3-(mercaptomethyl)-1,2,3-benzotriazin-4 (3H)-one

Physical Properties
Physical description	Colorless crystals or a brown, waxy solid.
Boiling point	decomposes	Molecular weight	317.3
Freezing point/melting point	163°F	Vapor pressure	8 X 10-9 mmHg
Flash point		Vapor density
Specific gravity	1.44	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0300
Sampling group
Sampler/Sampling media	OSHA versatile sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg) with GFF enclosed [SKC 226-30-16]
Sampling time^*	480 min
Sampling volume (TWA)^*	480 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FPD
Method reference	OSHA PV2087 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	0.2 mg/m³	REL-TWA	0.2 mg/m³	TLV-TWA		PEL-TWA	0.2 mg/m³
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	Y	Skin notation	Y	Skin notation	Y	Skin notation	Y
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes: Visit the ACGIH TLV site for specific data dermal sensitizer (DSEN), BEI®		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	10 mg/mg³
Carcinogenic classifications: TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Azinphos-methyl

NIOSH: Pocket Guide to Chemical Hazards - Azinphos-methyl

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Azinphos-methyl. See annual publication for most recent information.
Buratti, F.M., Volpe, M.T., Meneguz A., Vittozzi, L. and Testai, E.: CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes. Toxicol. Appl. Pharmacol. 186(3): 143-154, 2003.
McCurdy, S.A., et al.: Assessment of azinphosmethyl exposure in California peach harvest workers. Arch. Environ. Health 49(4): 289-296, 1994.
Pohanish, R.P. (editor): Azinphos-Methyl. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 270-273.

Last Updated Date : 04/03/2024

AZINPHOS-METHYL (GUTHION)†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References