HEXAMETHYLENE DIISOCYANATE BIURET

Chemical Identification

CAS # 4035-89-6
Formula

C₂₃H₃₈N₆O₅

Synonyms

HDIB; 1,6-hexamethylene diisocyanate biuret; HDI biuret; biuret of hexamethylenediisocyanate; Desmodur N, tris(6=isocyanatohexyl) biuret

Physical Properties

Physical description Thick liquid
Boiling point Molecular weight 478.6
Freezing point/melting point -2.2°F Vapor pressure
Flash point Vapor density 1.114
Specific gravity Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA

Analyte code (IMIS no.) D668
Sampling group
Sampler/Sampling media Isocyanate Sampling Filter Kit - GFF (37 mm, open-faced) coated with 1 mg 1-(2-pyridyl)piperazine [SLTC103]
Sampling time*

15 min

Sampling volume (TWA)*

15 L

Sampling flow rate (TWA)*

1 L/min

Sampling volume (STEL/Peak/C)*

Sampling flow rate (STEL/Peak/C)*

Analytical method instruments UHPLC
Method reference OSHA 5002 (fully validated)
Notes

Results may not reflect accurate exposures to the polymeric forms of isocyanates. Refrigerate coated filters until used. Sample open-faced!!

Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method

Wipe Sampler/Sampling media

Bulk Method

On-Site Screening Techniques

Device Hazard Assessment Test Kit for Aliphatic Isocyanates
Model/Type 769-1003
Sampling information
(see manufacturer instructions)
Isocyanate Surface and Dermal Sampling, Hazard Assessment Test Kit for Aliphatic Isocyanates

Exposure Limits

OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

REL-TWA

TLV-TWA

PEL-TWA

PEL-STEL

REL-STEL

TLV-STEL

PEL-STEL

PEL-C

REL-C

TLV-C

PEL-C

Skin notation

NA

Skin notation

NA

Skin notation

NA

Skin notation

NA

Notes:

Not established

Notes:

Not established

Notes:

Not established

Notes:

Not established

Health factors: See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Notes:

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

Last Updated Date : 04/02/2025