4-AMINOPYRIDINE

Chemical Identification
CAS #	504-24-5
Formula	C₅H₆N₂
Synonyms	4-pyridinamine; avitrol

Physical Properties
Physical description	White crystalline material with no odor.
Boiling point	524.3°F	Molecular weight	94.13
Freezing point/melting point	604.4°F	Vapor pressure
Flash point		Vapor density
Specific gravity	1.2607	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	A173
Sampling group
Sampler/Sampling media	2 GFFs (37 mm) coated with sulfuric acid, in 3-piece cassette, separated by the ring section [SKC 225-9004]
Sampling time^*
Sampling volume (TWA)^*	240 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-NPD
Method reference	OSHA PV2143 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Pyridine, 4-amino

NIOSH: Pocket Guide to Chemical Hazards - Pyridine, 4-amino

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: US1750000
Hayes, K.C.: The use of 4-aminopyridine (fampridine) in demyelinating disorders. CNS Drug Rev. 10(4): 295-316, 2004.
Pohanish, R.P. (editor): 4-Aminopyridine. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 141-143.
Velez, L., Shirazi, F., Goto, C., Shepherd, G. and Roth, B.A.: Opisthotonic posturing with neuromuscular irritability attributable to 4-aminopyridine ingestion by a healthy pediatric patient. Pediatrics 111(1): e82-84, 2003.

Last Updated Date : 12/15/2020

4-AMINOPYRIDINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References