ESTRIOL

Chemical Identification
CAS #	50-27-1
Formula	C₁₈H₂₄O₃
Synonyms	Destriol; 1,3,5-estratriene-3-β,16-α, 17-β-triol; trihydroxyestrin

Physical Properties
Physical description	Odorless white crystals.
Boiling point		Molecular weight	288.39
Freezing point/melting point	282°C	Vapor pressure
Flash point		Vapor density
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	E321
Sampling group
Sampler/Sampling media	GFF Gelman Type A (37 mm) in 3-piece cassette no backup pad [SKC 225-706]
Sampling time^*	240 min
Sampling volume (TWA)^*	240 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA PV2001 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: NTP, IARC-1		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

No Author: Estrogens, Steroidal . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
No Author: Synapause-E3® 2 mg (tablets). South African Electronic Package Inserts.
Kuiper, G.G.J.M., et al.: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138(3): 863-870, 1997.
Longcope, C.: Estriol production and metabolism in normal women. J. Steroid Biochem. 20(4B): 959-962, 1984.
Loose-Mitchell, D.S. and Stancel, G.M.: Estrogens and Progestins (Chapter 58). In, Goodman & Gilman's The Pharmacological Basis of Therapeutics, 10th Ed. J.G. Hardman, L.E. Limbird and A.G. Gilman, eds. New York: McGraw-Hill, 2001, pp. 1597-1634.
Weiderpass, E., et al.: Low-potency oestrogen and risk of endometrial cancer: a case-control study. Lancet 353(9167): 1824-1828, 1999.

Last Updated Date : 12/28/2020

ESTRIOL

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References