N-NITROSODIPROPYLAMINE

Chemical Identification
CAS #	621-64-7
Formula	C₆H₁₄N₂O
Synonyms	NDPA; di-n-propylnitrosamine; N-nitrosodi-n-propylamine; DPNA; DPN; N-nitroso-N-propyl-1-propanamine; propylamine, N-nitroso-N-di; dipropylnitrosamine; N-propyl-N-nitrosopropylamine

Physical Properties
Physical description	Clear to pale yellow liquid.
Boiling point	403°F	Molecular weight	130.19
Freezing point/melting point		Vapor pressure
Flash point		Vapor density
Specific gravity	0.9163	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1948
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*	75 min
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 27 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: NTP, IARC-2B, EPA-B2		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-nitrosodi-n-propylamine

NIOSH: Pocket Guide to Chemical Hazards - N-nitrosodi-n-propylamine

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: JL9700000.
U.S. EPA Integrated Risk Information System: N-Nitrosodi-N-propylamine (CASRN 621-64-7).
Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profile for N-nitrosodi-n-propylamine. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, 1989.
California Department of Health Services: California drinking water; activities related to NDMA and other nitrosamines, 2005.
No Author: N-Nitrosodi-n-Propylamine . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Pohanish, R.P. (editor): N-Nitrosodipropylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1736-1738.
Teiber, J.F. and Hollenberg, P.F.: Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine. Carcinogenesis 21(8): 1559-1566, 2000.
Teiber, J.F., Macé, K. and Hollenberg, P.F.: Metabolism of the β-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-β-hydroxypropylpropylamine and N-nitroso-β-oxypropylpropylamine. Carcinogenesis 22(3): 499-506, 2001.

Last Updated Date : 01/22/2024

N-NITROSODIPROPYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References