N-NITROSODIETHANOLAMINE

Chemical Identification
CAS #	1116-54-7
Formula	C₄H₁₀N₂O₃
Synonyms	NDELA; DELNA; 2,2'-iminodi-N-nitrosoethanol; bis(β-hydroxyethyl)nitrosamine; nitrosoiminodiethanol; 2,2'-(nitrosoimino) bis[ethanol]; N-nitrosobis(2-hydroxyethyl)amine; NCI-C55583; diethylamine, 2,2'-dihydroxy-N-nitroso; diethanolnitrosamine

Physical Properties
Physical description	Yellow to dark brown very viscous liquid with no distinct odor.
Boiling point	237°F at 1.5 mmHg	Molecular weight	134.16
Freezing point/melting point		Vapor pressure
Flash point		Vapor density
Specific gravity	1.28	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0907
Sampling group
Sampler/Sampling media	GFF Gelman Type A (37 mm) in 3-piece cassette no backup pad [SKC 225-706]
Sampling time^*	240 min
Sampling volume (TWA)^*	480 L
Sampling flow rate (TWA)^*	2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA 31 (fully validated)
Notes	Sample open-faced!! Store samples in freezer.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method	Limit the amount of bulk submitted to 1 g or 1 mL.

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: NTP, IARC-2B, EPA-B2		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosodiethanolamine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosodiethanolamine

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KL9550000.
U.S. EPA Integrated Risk Information System: N-Nitrosodiethanolamine (CASRN 1116-54-7).
Ducos, P. and Gaudin, R.: N-nitrosodiethanolamine urinary excretion in workers exposed to aqueous metalworking fluids. Int. Arch. Occup. Environ. Health 76(8): 591-597, 2003.
Fuchs, J., Burg, J., Hengstler, J.G., Bolm-Audorff, U. and Oesch, F.: DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. Mutat. Res. 342(1-2): 95-102, 1995.
Loeppky, R.N., Goelzer, P. and Chen, Y.: DNA adducts from N-nitrosodiethanolamine and related β-oxidized nitrosamines in vivo: (32)P-postlabeling methods for glyoxal- and O(6)-hydroxyethyldeoxyguanosine adducts. Chem. Res. Toxicol. 15(4): 470-482, 2002.
No Author: N-Nitrosodiethanolamine . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.

Last Updated Date : 01/05/2021

N-NITROSODIETHANOLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References