N-METHYL-2-PYRROLIDINONE

Chemical Identification
CAS #	872-50-4
Formula	C₅H₉NO
Synonyms	NMP; N-methylpyrrolidinone; N-methyl-2-pyrrolinone; 1-methyl-5-pyrrolidinone; methylpyrrolidone; N-methylpyrrolidone; composite constituent

Physical Properties
Physical description	A clear colorless liquid with a fish-like odor.
Boiling point	396°F	Molecular weight	99.13
Freezing point/melting point	-9°F	Vapor pressure
Flash point	204°F	Vapor density	3.4
Specific gravity	1.03	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating	2	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	M139
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*	50 min
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA PV2043 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA	1 ppm (4 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	Y
Notes: Not established		Notes: Not established		Notes: BEI® only		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Methyl-2-pyrrolidone

NIOSH: Pocket Guide to Chemical Hazards - N-Methyl-2-pyrrolidone

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - N-METHYL-2-PYRROLIDONE. See annual publication for most recent information.
Åkesson, B. and Jönsson, B.A.G.: Major metabolic pathway for N-methyl-2-pyrrolidone in humans. Drug Metab. Dispos. 25(2): 267-269, 1997.
Åkesson, B., Carnerup, M.A. and Jönsson, B.A.G.: Evaluation of exposure biomarkers from percutaneous absorption of N-methyl-2-pyrrolidone. Scan. J. Work Environ. Health 30(4): 306-312, 2004.
Jönsson, B.A.G. and Åkesson, B.: Human experimental exposure to N-methyl-2-pyrrolidone (NMP): toxicokinetics of NMP, 5-hydroxy-N-methyl-2-pyrrolidone, N-methylsuccinimide and 2-hydroxy-N-methylsuccinimide (2-HMSI), and biological monitoring using 2-HMSI as a biomarker. Int. Arch. Occup. Environ. Health 76(4): 267-274, 2003.
Leira, H.L., Tiltnes, A., Swendsen, K. and Vetlesen, L.: Irritant cutaneous reactions to N-methyl-2-pyrrolidone (NMP). Contact Dermatitis 27(3): 148-150, 1992.
Ligocka, D., Lison, D. and Haufroid, V.: Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism. Arch. Toxicol. 77(5): 261-266, 2003.
Malley, L.A., et al.: Chronic toxicity and oncogenicity of N-methylpyrrolidone (NMP) in rats and mice by dietary administration. Drug Chem. Toxicol. 24(4): 315-338, 2001.
Solomon, G.M., Morse, E.P., Garbo, M.J. and Milton, D.K.: Stillbirth after occupational exposure to N-methyl-2-pyrrolidone. A case report and review of the literature. J. Occup. Environ. Med. 38(7): 705-713, 1996.

Last Updated Date : 01/05/2021

N-METHYL-2-PYRROLIDINONE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References