PROGESTERONE

Chemical Identification
CAS #	57-83-0
Formula	C₂₁H₃₀O₂
Synonyms	corlutin; luteohormone; pregnenedione; pregn-4-ene-3,20-dione; progestin; progestone

Physical Properties
Physical description	White odorless crystals or powder.
Boiling point		Molecular weight	314.51
Freezing point/melting point	250-252°F	Vapor pressure
Flash point		Vapor density
Specific gravity	1.171	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	P446
Sampling group
Sampler/Sampling media	GFF Gelman Type A (37 mm) in 3-piece cassette no backup pad [SKC 225-706]
Sampling time^*	240 min
Sampling volume (TWA)^*	240 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA PV2001 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-2B, NTP		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Progesterone

NIOSH: Pocket Guide to Chemical Hazards - Progesterone

Literature References

National Institute for Occupational Safety and Health: NIOSH Alert: Preventing Occupational Exposure to Antineoplastic and Other Hazardous Drugs in Health Care Settings. NIOSH Publication No. 2004-165.
Andréen, L., Sundstrom-Poromaa, I., Bixo, M., Andersson, A., Nyberg, S. and Bäckström, T.: Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone. Psychoneuroendocrinology 30(2): 212-224, 2005.
Bélanger, A., et al.: Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men. J. Clin. Endocrinol. Metab. 79(4): 1086-1090, 1994.
Golub, M.S., Kaufman, F.L., Campbell, M.A. Li, L.-H., et al.: Evidence on the developmental and reproductive toxicity of progesterone (draft). Reproductive and Cancer Hazard Assessment Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, (August) 2004, 71 pp.
No authors listed: Progesterone (CAS No. 57-83-0). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2005.
Soderpalm, A.H., Lindsey, S., Purdy, R.H., Hauger, R. and Wit de H.: Administration of progesterone produces mild sedative-like effects in men and women. Psychoneuroendocrinology 29(3): 339-354, 2004.
Trévoux, R., De Brux, J., Castaner, M., Nahoul, K., Soule, J.-P. and Scholler, R.: Endometrium and plasma hormone profile in the peri-menopause and post-menopause. Maturitas 8(4): 309-326, 1986.

Last Updated Date : 01/08/2021

PROGESTERONE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References