CHLOROBENZENE | OSHA.gov | Occupational Safety and Health Administration

CHLOROBENZENE†

Chemical Identification
CAS #	108-90-7
Formula	C₆H₅Cl
Synonyms	benzene chloride; chlorobenzol; MCB; monochlorobenzene; phenyl chloride

Physical Properties
Physical description	Colorless liquid with an almond-like odor.
Boiling point	270°F	Molecular weight	112.6
Freezing point/melting point	-50°F	Vapor pressure	8.8 mmHg
Flash point	75°F	Vapor density	3.88
Specific gravity	1.11	Ionization potential	9.07 eV
Lower explosive limit (LEL)	1.3%	Upper explosive limit (UEL)	9.6%
NFPA health rating	3	NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0620
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.01-0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	NIOSH 1003 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	75 ppm (350 mg/m³)	REL-TWA		TLV-TWA		PEL-TWA	10 ppm (46 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes: See Appendix D, Substances with No Established RELs		Notes: Visit the ACGIH TLV site for specific data BEI®		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	1000 ppm
Carcinogenic classifications: EPA-D, TLV-A3		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Chlorobenzene

NIOSH: Pocket Guide to Chemical Hazards - Chlorobenzene

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Chlorobenzene. See annual publication for most recent information.
EPA Air Toxics Website: Chlorobenzene. U.S. Environmental Protection Agency Technology Transfer Network.
Arutjunov, V.D., Batsura, Ju.D., Gribova, I.A. and Kruglikov G.G.: Scanning electron-microspic and light-optic investigations of erythrocytes in toxic anaemia. Br. J. Ind. Med. 38(1): 72-75, 1981.
Knecht, U. and Woitowitz, H.-J.: Human toxicokinetics of inhaled monochlorobenzene: latest experimental findings regarding re-evaluation of the biological tolerance value. Int. Arch. Occup. Environ. Med. 73(8): 543-554, 2000.
National Toxicology Program: NTP Toxicology and Carcinogenesis Studies of Chlorobenzene (CAS No. 108-90-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Natl. Toxicol. Program Tech. Rep. Ser. 261: 1-220, 1985.
Nedelcheva, V., Gut, I., Soucek, P. and Frantik, E.: Cytochrome P450 catalyzed oxidation of monochlorobenzene, 1,2- and 1,4-dichlorobenzene in rat, mouse, and human liver microsomes. Chem. Biol. Interact. 115(1): 53-70, 1998.
Pohanish, R.P. (editor): Dichlorobenzenes. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 799-804.

Last Updated Date : 04/30/2024

CHLOROBENZENE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References