RESORCINOL

Chemical Identification
CAS #	108-46-3
Formula	C₆H₆O₂
Synonyms	1,3-benzenediol; m-benzenediol; 1,3-dihydroxybenzene; m-dihydroxybenzene; 3-hydroxyphenol; m-hydroxyphenol

Physical Properties
Physical description	White needles, plates, crystals, flakes, or powder with a faint odor. Turns pink on exposure to light if not completely pure.
Boiling point	531°F	Molecular weight	110.11
Freezing point/melting point	228-232°F	Vapor pressure	0.0002 mmHg at 77°F
Flash point	261°F	Vapor density	3.79
Specific gravity	1.27 at 68°F	Ionization potential	8.63 eV
Lower explosive limit (LEL)	1.4% at 738°F	Upper explosive limit (UEL)	1.4% at 200°F
NFPA health rating	3	NFPA fire rating	1
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	2221
Sampling group
Sampler/Sampling media	OSHA versatile sampler (OVS-7) - 13 mm XAD-7 tube (270/140 mg) with GFF enclosed (no longer available) [SKC 226-57]
Sampling time^*
Sampling volume (TWA)^*	60 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA PV2053 (partially validated)
Notes	Media no longer available. SKC recommends the 200/100 mg variant with the same media [SKC 226-57].
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA	10 ppm (45 mg/m³)	TLV-TWA	10 ppm [1992]	PEL-TWA	10 ppm (45 mg/m³)
PEL-STEL		REL-STEL	20 ppm (90 mg/m³)	TLV-STEL	20 ppm [1992]	PEL-STEL	20 ppm (90 mg/m³)
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	N	Skin notation	N	Skin notation	N
Notes: Not established		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-3, TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Resorcinol

NIOSH: Pocket Guide to Chemical Hazards - Resorcinol

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Resorcinol. See annual publication for most recent information.
Cassano, N., Alessandrini, G., Mastrolonardo, M. and Vena, G.A.: Peeling agents: toxicological and allergological aspects. J. Eur. Acad. Dermatol. Venereol. 13(1): 14-23, 1999.
Duran, B., Gursoy, S., Cetin, M., Demirkoprulu, N., Demirel, Y. and Gurelik, B.: The oral toxicity of resorcinol during pregnancy: a case report. J. Toxicol. Clin. Toxicol. 42(5): 663-666, 2004.
Hahn, S., Kielhorn, J., Koppenhöfer, J., Wibbertmann, A. and Mangelsdorf, I.: Concise International Chemical Assessment Document 71 Resorcinol.
Levin, C.Y. and Maibach, H.: Exogenous ochronosis. An update on clinical features, causative agents and treatment options. Am. J. Clin. Dermatol. 2(4): 213-217, 2001.
No authors listed: Resorcinol. IARC Monogr. Eval. Carcinog. Risks Hum. 71(Pt. 3): 1119-1131, 1999.
No authors: Toxicology and carcinogenesis studies of resorcinol (CAS No. 108-46-3) in F344 rats and B6C3F1 mice (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 403: 1-234, 1992.
Pohanish, R.P. (editor): Resorcinol. In, Sittig?s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2000-2002.
Yeung, D., Kantor, S., Nacht, S. and Gans, E.H.: Percutaneous absorption, blood levels, and urinary excretion of resorcinol applied topically in humans. Int. J. Dermatol. 22(5): 321-324, 1983.

Last Updated Date : 01/11/2021

RESORCINOL

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References