- Synonyms: Methylcyanide; ACN
- OSHA IMIS Code Number: 0060
- Chemical Abstracts Service (CAS) Registry Number: 75-05-8
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AL7700000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1648 127
- NIOSH Pocket Guide to Chemical Hazards, Acetonitrile: chemical description, physical properties, potentially hazardous incompatibilities, and more.
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 20 ppm, 34 mg/m3 TWA; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 20 ppm, 34 mg/m3 TWA
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 ppm
- Potential Symptoms: Nausea, vomiting; headache; hypersalivation; chest pain or tightness; profuse sweating; abdominal pain and hematemesis; weakness, stupor; respiratory depression, metabolic acidosis; convulsions; tachycardia, shock; eye irritation
- Health Effects: Irritation-Eye, Nose, Throat---Mild (HE16); Acute Toxicity---Cyanosis, cardiac, respiratory arrest (HE4). Ingestion Acute: TDLO (human) 570 mg/kg
- Affected Organs: Kidneys, liver, CVS, CNS, lung, skin, eyes
- Notes: Metabolized by liver to cyanide
- (profuse sweating, hypersalivation, cardiac and respiratory arrest) Cohrssen, B. Cyanides and nitriles. In Patty's Toxicology, 5th Ed., Vol. 4, Bingham, E., Cohrssen, B., Powell, C.H., eds., New York: John Wiley & Sons, Inc., pp. 1406-1410, 2001.
- (headache, respiratory depression, metabolic acidosis, death) Robles, H. Acetonitrile. In Encyclopedia of Toxicology, Vol. 1, Wexler, P., ed. New York: Academic Press, pp. 16-17, 1998.
- (abdominal pain, hematemesis) Sitting, M. Acetonitrile. Handbook of Toxic and Hazardous Chemicals and Carcinogens, Vol. 1, pp. 28-30, 1991.
Date Last Revised: 11/02/2001
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Charcoal Tube (400/200 mg sections)
- analytical solvent: Benzene
- alternate solvent: Acetone
- alternate solvent: (99:1) Carbon Disulfide:Dimethylformamide
- maximum volume: 25 Liters
- maximum flow rate: 0.2 L/min TWA
- maximum volume: 3 Liters
- maximum flow rate: 0.2 L/min STEL
- current analytical method: Gas Chromatography; GC/FID
- method reference: NIOSH Analytical Method (NIOSH 1606 (PDF))
- method classification: Fully Validated
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