OSHA Directive CPL 02-02-078 and CDC Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings address cleaning practices when cleaning the room of a person who has infectious TB.

• Follow routine cleaning procedures (e.g., use an EPA-registered disinfectant).
  • The EPA provides lists of Registered Tuberculocide Products Effective Against Mycobacterium tuberculosis for tuberculocidal cleaning.
• Follow isolation practices and wear a Class N95 or more protective respirator while cleaning rooms of infectious patients.
• Ventilate rooms occupied by infectious patients according to the CDC's recommendations for minimum removal efficiency of 99.97% of Mycobacterium tuberculosis.
  • Until the ventilation of a room is complete: leave warning signs posted at the entrance to the room after the room is vacated by an infectious patient; and use respirators if entering the room.
• For final cleaning of the isolation room after a patient has been discharged, personal protective equipment (PPE) is not necessary if the room has been ventilated for the amount of time indicated in CDC Guidelines.