Evaluating Exposure

Sampling and Analysis

OSHA

• OSHA Occupational Chemical Database. OSHA's premier one-stop shop for occupational chemical information. It compiles information from several government agencies and organizations. Information available on the pages includes chemical identification and physical properties, exposure limits, sampling information, and additional resources.
  • Hexamethylene Diisocyanate
  • Hexamethylene Diisocyanate Biuret
  • 1,6-Hexamethylene Diisocyanate Homopolymer
  • Isophorone Diisocyanate
  • Methyl Isocyanate
  • Methylene Bisphenyl Isocyanate (MDI)
  • 1,5-Naphthalene Diisocyanate

For additional information, see OSHA's Sampling and Analysis Safety and Health Topics Page.

National Institute for Occupational Safety and Health (NIOSH)

• NIOSH Manual of Analytical Methods (NMAM). NMAM is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed. NMAM also includes chapters on quality assurance, sampling, portable instrumentation, etc.
  • Isocyanates. Method No. 5522.

Other

• U.K. Health and Safety Executive Method 25/2
• The following are analysis methods for specific isocyanate compounds. It is often desirable to determine the amount of free isocyanate, not just the specific compound. Several methods have been suggested to accomplish this. However, all have had serious problems when applied to field sampling.
  • Streicher, RP, et al. Investigation of the ability of MDHS method 25 to determine urethane-bound isocyanate groups. American Industrial Hygiene Association Journal. 1995;56(5):437-42.
  • Key-Schwartz, RJ. Analytical problems encountered with NIOSH method 5521 for total isocyanates. American Industrial Hygiene Association Journal. 1995;56(5):474-9.
  • Maitre, A., et al. Biological monitoring of occupational exposure to toluene diisocyanate. Int. Arch. Occup. Environ. Health. 1993;65:97-100.
  • Documentation of the threshold limit values and biological exposure indices. American Conference for Government Industrial Hygienists (ACGIH). 1991;6:1581-9.